CURCUMIN XTRA-MAX(TM) is an advanced version of curcumin (BCM-95® | Bio-Curcumin®) and is 8Xs more absorbable than regular 95% standardized curcumin extract. Therefore, 500mg of Curcumin Xtra-Max is approximately equivalent to 3500 mg 4000 mg of regular 95% standardized curcumin extract. Many longevity experts consider curcumin as one of the most foremost anti-aging herbs, providing a broad spectrum of anti-aging properties. MODULATION OF INFLAMMATORY RESPONSE. Research indicates that curcumin plays a key role in modulating the inflammation response in the body, by the inhibition of the activation of NF-kappaB in the body. NF-kappaB operates at the gene level, and activates the genes responsible for the inflammatory response. Over activation of NF-kappaB is believed to be responsible for many disease processes in the body, and may also be an important factor in accelerating the aging process. Curcumin further suppresses inflammatory gene activation by inhibiting the gene signaling protein HMGB1 - which is a powerful activator of cytokine inflammation. (Kim DC, et al. Inflamm. Res. 2011 Dec.) CARDIOVASCULAR FUNCTION. In lab animals, curcumin has been shown to promote cardiac repair and helps preserve cardiac function following myocardial infarction - heart attack (Wang et al, 2012). ANTI-AGING AND LONGEVITY. Research studies confirm that curcumin has considerable anti-aging and longevity activity. The lifespan extension seen Drosophila (fruit fly), after curcumin administration, was associated with increased SOD (superoxide dismutase) a powerful cellular antioxidant and decreased levels aging molecules lipofuscin and malondialdehyde. Tetrahydrocurcumin, a metabolite of curcumin, significantly increased longevity of Drosophila by increasing activation of FOXO and Sirt2 genes. (Shen, LR, et al 2013)
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