The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. Name: Recombinant Human IGF-I LR3 (Carrier-Free) Cat. No.: 21-9012 Alternative Names: Long R3 IGF-I, Insulin-like Growth Factor-I, Somatamedin C, IGF-IA Amino Acid Sequence: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA Authenticity: Verified by N-terminal and Mass Spectrometry analyses (when applicable). Bioactivity: The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. Endotoxin Level: Endotoxin level is <0.1 ng/μg of protein (<1EU/μg). Molecular Mass: Recombinant Human IGF-I LR3 is a 9.1 kDa, single, non-glycosylated polypeptide chain containing 83 amino acid residues. Protein Content: Content Verified by UV Spectroscopy and/or SDS-PAGE gel. Purity (%): 98 Source: E.coli Reactivity: Human Research Areas: Inflammation, Wound Healing, Bone, Skeletal, Cartilage, Proliferation, Angiogenesis/Cardiovascular, Diabetes/Weight Regulation Reconstitution: See Certificate of Analysis (COA) for lot specific reconstitution information. Application: Bioassay Orders Placed Before 2pm EST, Will Ship Same Day for Next Day Delivery. Orders Received After 2pm EST, Will Ship The Next Business Day for Next Day Delivery All orders ship next day delivery.
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