When adding new fish or changing water do I have to use the entire 5ml/10gallon rule ?

I would do it if it were me. Most fish come from pet stores that are severly overstocked and under maintained so they are already stressed when you bring them home. Add to that the fact that they are being moved for the umpteeth time and they can use all the help they can get. I will say that I do use half doses when I move my fish from one tank to another only because they tanks are well maintained and the water parameters are pretty much the same so the fish are less stressed. Other people may have different opinions but this is my process and it works for me. I have four tanks. I have a 125, 90, 55 and a 40. I have been in the hobby for over 15 years. I also keep two aquatic turtles as well. Hope this helps.

any views on this product versus API's stresscoat?

Different products, API is a water conditioner, stressguard is an antiseptic for open wounds, cuts. I used StressGuard occasionally and API on water changes.

Do you have to remove purigen from your filter

No. Generally Seachem products are safe to use with other Seachem products. Normal filters, nor purigen filters have to be removed when using Stress Guard. It's perfectly safe.

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Seachem Laboratories Stress Guard 500Ml

Product ID: 64783399

Details

Brand
Seachem
Item Form
Liquid
Item Weight
1.15 Pounds
Liquid Volume
500
Number of Packs
1

⚡protein-active colloids for rapid wound healing

💧500ml premium liquid formula

🛡️pH neutral 7.0, safe for all aquariums

€ 68.20

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Sold byAmazon BelgiumDelivered byDesertcartCustomer service byDesertcartReturns14 days · 30 with PRO

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Description

🛡️ Protect, Heal, Thrive – Because Your Fish Deserve the Best!

TRUSTED BY THOUSANDS - Rated 4.8 stars by nearly 4,000 users, making it the go-to slime coat protection for serious aquarists.
AQUARIUM SAFE FORMULA - pH neutral at 7.0, it won’t alter water chemistry or clog filtration systems, unlike competitors.
MEDICATION COMPATIBLE - Works seamlessly with all treatments except copper-based ones, ensuring no interference with your care routine.
ULTIMATE STRESS REDUCTION - Calms fish instantly during handling and transport, minimizing shock and ammonia toxicity.
ADVANCED HEALING TECHNOLOGY - Protein-active colloids bind to wounds, acting as a liquid bandage to accelerate recovery and prevent infections.

Seachem Laboratories Stress Guard 500ml is a premium liquid slime coat protector designed to reduce fish stress and ammonia toxicity during handling or transport. Its unique protein-active colloids target wounds to promote rapid healing and reduce infection risk, all while maintaining a neutral pH of 7.0 that won’t disrupt aquarium balance. Compatible with most medications and highly rated by thousands, it’s the essential treatment for any professional or passionate aquarist.

Specifications

ASIN	B001F0KX06
Best Sellers Rank	#23,403 in Pet Supplies ( See Top 100 in Pet Supplies ) #502 in Water Treatments
Brand Name	Seachem
Customer Reviews	4.8 4.8 out of 5 stars (3,805)
Global Trade Identification Number	00000116052306
Included Components	1 piece Seachem Laboratories Stress Guard 500Ml
Item Form	Liquid
Item Type Name	Seachem Laboratories Stress Guard
Item Weight	1.15 Pounds
Liquid Volume	500 Millilitres
Manufacturer	SEACHEM LABORATORIES, SEACHEM LABORATORIES
Manufacturer Contact Information	SEACHEM LABORATORIES
Manufacturer Part Number	523
Model Number	523
Number Of Items	1
Number of Packs	1
Packer Contact Information	SEACHEM LABORATORIES
Pet Type	Fish
Target Species	Fish
UPC	000116052306
Unit Count	500.0 Milliliters

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