Atomoxetine hydrochloride, also known as tomoxetine hydrochloride, is a commonly prescribed treatment for a variety of ADHD subtypes. This compound also displays minor antidepressant activity, but is not active enough of its own to warrant prescription use as a treatment for depression. Atomoxetine hydrochloride inhibits norepinephrine transporters (NET), increasing norepinephrine and dopamine levels, and inhibits serotonin transporters (SERT) and N-methyl D-aspartate (NMDA) receptors to a lesser degree. Perhaps due to its modulation of neurotransmitters, atomoxetine is also currently being studied as a potential relapse prevention therapy in recently abstinent substance abuse subjects.
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