Description Denosyl and Marin support the liver through differing actions and may be used individually or in combination. Denamarin is one such patented combination liver supplement for dogs and cats containing both pure and stabilized S-Adenosylmethionine (SAMe) and silybin-phosphatidylcholine complex. Both SAMe and silybin have been shown to markedly increase levels of antioxidants formed when cats and dogs metabolize it. Silybin also helps with liver cell regeneration and enhances levels of glutathione, the liver’s major “detoxifying” agent. Denamarin has no known side-effects. Directions for Use: Tablets should be given on an empty stomach at least one hour before a meal for optimal absorption ( overnight fast preferred). For owners who find it difficult to administer tablets to their pets, Denamarin tablets may be disguised in a small bite of food. The number of tablets administered may be gradually reduced, or increased, at any time at the recommendation of your veterinarian. For pets 13-34 lbs. = 1 tablet per day Storage: Store in a cool dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled. How does Denamarin work? When liver function is compromised, the exact cause can often be difficult to determine. Supporting the liver, regardless of the cause, is essential to keep it working properly. Administering SAMe (S-Adenosylmethionine), which is found in Denamarin, has been shown to markedly increase liver levels of glutathione,1,2 an important compound for liver health formed when SAMe is metabolized. The SAMe in Denamarin has also been shown to help protect liver cells from cell death3,4 and may help cell repair and regeneration.5 Denamarin also helps support your pet’s liver through the administration of silybin. Silybin is an active part of an extract from milk thistle, known as silymarin, and has been shown to support liver function by helping maintain a healthy oxidative balance. The new chewable tablets of Denamarin allow dogs to receive SAMe and silybin in a tasty treat, eliminating the need to "pill" your dog daily. Additionally, the chewable tablets allow for quicker uptake of the SAMe and less variability between dogs when compared to enteric-coated tablets. While best known for supporting the liver in dogs and cats Denamarin also has a place in supporting brain health. Research is looking into dog aging and associated decreases in levels of S-Adenosylmethionine (SAMe) in cerebrospinal fluid, which surrounds the brain. Denamarin provides SAMe in a stabilized form to help with brain health and act as a neuroprotector. Denamarin also provides a bioavailable form of silybin which supports oxidative balance. Denamarin has no known serious side-effects. Your veterinarian can evaluate the length of support needed through follow-up examinations, blood work, and/or other laboratory work. At home, watch for improvements in your pet’s attitude, appetite, and activity level.
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