Mature myostatin is obtained by proteolytic processing of a biologically-inactive precursor protein, which contains an N-terminal propeptide of 243 amino acid residues. Myostatin-Propeptide exhibits high binding affinity for myostatin, and has been shown to be a potent inhibitor of myostatin. Over-expression of myostatin-propeptide in mice resulted in large increases (up to 200%) in skeletal muscle mass, similar to those observed in myostatin knockout mice. Name: Recombinant Human Myostatin Propeptide (Carrier-Free) Cat. No.: 21-9068 Alternative Names: No Amino Acid Sequence: MNENSEQKEN VEKEGLCNAC TWRQNTKSSR IEAIKIQILS KLRLETAPNI SKDVIRQLLP KAPPLRELID QYDVQRDDSS DGSLEDDDYH ATTETIITMP TESDFLMQVD GKPKCCFFKF SSKIQYNKVV KAQLWIYLRP VETPTTVFVQ ILRLIKPMKD GTRYTGIRSL KLDMNPGTGI WQSIDVKTVL QNWLKQPESN LGIEIKALDE NGHDLAVTFP GPGEDGLNPF LE Authenticity: Verified by N-terminal and Mass Spectrometry analyses (when applicable). Bioactivity: Determined by its ability to neutralize the Myostatin inhibitory effect of Mouse MPC-11 cells. The expected ED50 is 0.01–0.04 ug/ml in the presence of 50 ng/ml Myostatin. Endotoxin Level: Endotoxin level is <0.1 ng/μg of protein (<1EU/μg). Molecular Mass: Recombinant Human Myostatin-Propeptide is a 27.8 kDa protein consisting of 244 amino acid residues. Protein Content: Content Verified by UV Spectroscopy and/or SDS-PAGE gel. Purity (%): 98 Source: E.coli Reactivity: Human Research Areas: Proliferation, Angiogenesis/Cardiovascular, Bones, Skeletal, Cartilage, Diabetes/Weight Regulation Reconstitution: See Certificate of Analysis (COA) for lot specific reconstitution information. Application: Bioassay Orders Placed Before 2pm EST, Will Ship Same Day for Next Day Delivery. Orders Received After 2pm EST, Will Ship The Next Business Day for Next Day Delivery All orders ship next day delivery.
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